Abstract: Pharmaceutical Separation Engineering is a core course in pharmaceutical engineering,characterized by strong engineering focus and complex technologies. In response to the challenges faced in teaching,the course team has implemented a student-centered multi-dimensional teaching reform. The practice has shown that this multi-dimensional teaching reform not only enhances students' professional confidence and broadens their view of the cutting edge of the discipline,but also improves students' ability to analyze and solve complex engineering problems in pharmaceutical production,engineering design,and process development. This approach can provide reference for the reform of new engineering courses.