Abstract: In the current context where ideological and political education in universities is receiving increasing attention and the global impact of the COVID-19 pandemic, this study analyzes the issues existing in the ideological and political education of the microbiology and immunology course in pharmaceutical majors.Considering the reality of infectious disease epidemic prevention and control, feasibility recommendations are proposed for the reform of ideological and political education in the microbiology and immunology course tailored to "Double First-Class" universities.The study explores the transition from "ideological and political course" to "curriculum ideological and political education" and suggests strategies to integrate professional knowledge with ideological and political education and overall quality development, achieving a harmonious coordination and unity.