Abstract: Clinical Pharmacotherapeutics is a compulsory course for students major in clinical pharmacy,which aims to enhance students' abilities in drug use and prescription review.This course serves as a bridge between clinical medicine and pharmacy.Currently,most of the course designs focus on theoretical teaching,with relatively few practical courses and clinical cases.Students have difficulty integrating theoretical knowledge with clinical practice.This article explores the enrichment of teaching methods by teachers through the course positioning and training objectives,integrating advanced teaching methods such as "MOOCs" and "flipped classrooms," and incorporating ideological and political elements.It also provides a preliminary exploration of cultivating students' clinical thinking and medication skills,aiming to cultivate outstanding clinical pharmacy professionals who "understand medicine,excel in research,and proficient in applicable practice".