Abstract: With the rapid development of the medical field, the construction of the New Medical Education system has become an important direction in the current medical education reform.Clinical pharmacology is one of the essential courses for medical students, aimed at cultivating their ability to apply scientific clinical pharmacological thinking and methods to solve real clinical problems.This paper explores the use of a multifaceted interactive blended teaching model and methods in the reform of clinical pharmacology education, aimed at improving medical students’ learning outcomes and clinical application capabilities.The goal is to cultivate medical professionals with an international perspective, high medical ethics, solid medical knowledge and professional skills, and the ability to adapt to future healthcare needs.