Abstract: Experimental teaching is the core of the undergraduate teaching for pharmacy major undergraduates, and the developmental design experiment has promoted the reform of the experimental teaching courses. According to the requirements of pharmacology, pharmacy, pharmaceutical analysis, and pharmaceutical chemistry courses for undergraduates majoring in pharmacy, this article examines the significance of the comprehensive design experimental teaching mode of pharmacy centered on "Disease-Patient", and expounds the implementation of this experimental teaching mode from three aspects: the object of experimental teaching, the design of experimental teaching scheme and the evaluation of experimental teaching effect. This teaching mode has stimulated students' autonomy in pharmacy experiments, promoted the combination of students' theoretical study and practice, and improved the teaching effect of experimental courses.