Abstract: With the development of technology,economy,and globalization in the pharmaceutical industry,new requirements have been put forward for the cultivation of pharmaceutical professionals.Based on the background of "Double First-Class" construction in universities,this article explores the innovative talent training mode for top-notch pharmaceutical professionals.By optimizing the curriculum system,deepening teaching method reforms,integrating ethics education into the curriculum,establishing platforms for innovative entrepreneurship talent cultivation,and strengthening school-enterprise cooperation,it constructs a new model for training leading pharmaceutical professionals with innovation and entrepreneurship capabilities as the core.This research aims to provide valuable reference for the cultivation of pharmaceutical talents.