Abstract: Traditional medicinal chemistry teaching is characterized by teacher-centered instruction,an overemphasis on knowledge transmission at the expense of competency development,and a lack of individualized training,making it difficult to meet the demands of modern pharmaceutical education.Guided by the outcome-based education (OBE) philosophy,the teaching team integrates artificial intelligence into instructional practice by clarifying learning objectives,optimizing teaching content,innovating teaching methods,and improving the evaluation system.These reforms significantly enhance students' learning motivation,engagement,and comprehensive competencies.Practice results indicate that students' academic performance has improved markedly after the reform,and the teaching outcomes have been widely recognized by students.