Abstract: To improve the effectiveness of pharmaceutical education and enhance students' learning initiative,the teaching team adopted a knowledge construction approach in the Medicinal Chemistry course.Focusing on the topic of adrenergic receptor agonists,the instructional design follows a hierarchical learning progression—from understanding factual knowledge to mastering procedural skills,grasping underlying principles,and applying strategic reasoning.Course objectives were tiered accordingly.Through peer collaboration and differentiated knowledge scaffolding,students engaged in constructive learning processes and were guided toward deeper learning pathways.Findings indicate that these pedagogical innovations effectively enhance students' integrated clinical competencies and foster innovative thinking awareness.