Abstract: Pharmacology is an elective course offered in the pharmaceutical engineering major.In response to the requirements of undergraduate education in the new era and following the direction of "student-centered,output-oriented,continuous improvement" reform,the teaching team addresses the "pain points" of traditional teaching.Starting from enhancing pertinence,creating innovation,embodying advanced capabilities,and highlighting challenges,the team explores a mixed teaching innovation model for the pharmaceutical engineering major.By adopting an innovative approach that focuses on students' development,knowledge dissemination,emotional nurturing,and integration of critical thinking with political consciousness,the team aims to improve the teaching system and assessment methods.This includes the construction of a pharmacology curriculum that incorporates materials and cases related to critical thinking,and the realization of an overall design and multidimensional integration in the teaching reform process.