Abstract: Organic Reaction for Drug Synthesis is a compulsory course for pharmacy and pharmaceutical engineering majors,and it holds significant importance in cultivating talents for innovative and applied pharmaceutical research and production.By analyzing the current situation and issues in teaching the Organic Reaction for Drug Synthesis course,combined with the practical situation of Nanjing Medical University,this study discusses the teaching methods and evaluation system under the background of industry-university-research integration.This teaching model effectively stimulates students' interest and intrinsic learning motivation,and also has a certain impact on improving students' innovative and applicable abilities.