Abstract: In response to the contradiction between “the urgent demand for pharmaceutical industry deve-lopment in the Guangdong-Hong Kong-Macao Greater Bay Area and the insufficient supply of applied innovative talent from regional application-oriented undergraduate institutions”,this paper takes the central drug design experiment at Guangdong Pharmaceutical University as an example to explore a new pharmacology experiment teaching mode integrating research thinking.The teaching adopts a “Aalborg PBL（Problem-Based Learning） + research-driven project” approach, constructing a three-tier progressive curriculum knowledge system based on the need to carry research thinking, aiming to “solidify skill foundation, stimulate research thinking, and validate integration effects”.Based on the expression forms of research thinking, a comprehensive course assessment and evaluation system is established to promote the cultivation of research thinking.The teaching results show that the new teaching mode has stimulated students’ curiosity, enhanced their learning initiative, and is conducive to cultivating high-quality, application-oriented innovative talent.