Abstract: Aimed at the challenging and abstract thermodynamics section of physical chemistry,this paper introduces a teaching approach that collides with traditional Chinese medicine thinking,exploring the pathways for knowledge dissemination of physical chemistry in traditional Chinese medicine majors under the new engineering and medical science backgrounds.The collision between physical chemistry and traditional Chinese medicine thinking in teaching helps to improve the modern basic theoretical knowledge structure of traditional Chinese medicine major students,expand their professional thinking,and has a positive effect on promoting the cultivation of innovative talents specialized in socialism-characterized traditional Chinese medicine.