Abstract: Centering on the course syllabus and evaluation system, the teaching team conducted an inquiry-based reform of the membrane separation module in the Traditional Chinese Medicine Pharmaceutical Chemistry course, using the industrial problem of nanofiltration membrane pollutant removal as the thematic focus.Guided by curriculum design, quality assessment, training mode, and innovation capacity, the reform decomposes the process evaluation indicators of foundational verification, applied competence, and innovative capability into hierarchical levels.Student research teams were established to design experimental activities and develop an online ultrasonic cleaning scheme, effectively solving the enterprise’s technical challenge of nanofiltration membrane contamination.The reform achieved the expected pedagogical outcomes and demonstrated the value of integrating problem-oriented inquiry with competency-based education in pharmaceutical chemistry.