Abstract: Labor education is an essential approach to advancing the holistic education framework of “Five-Dimensional Parallel Cultivation” and the “Three-Whole Education” system.Pharmacy students are not only recipients of labor education but also its disseminators.To effectively promote labor education practices among pharmacy students, China Pharmaceutical University has developed a coordinated “1-2-3-4” labor education mechanism in response to existing challenges.Specifically, it establishes one guiding concept of “unity of knowledge and action”,constructs two complementary curriculum systems integrating theory and practice, consolidates tripartite resources from the university, local communities, and families, and refines a four-dimensional collaborative mechanism encompassing “support-evaluation-motivation-feedback”.This innovative framework provides a new path for nurturing well-rounded socialist builders and successors equipped with moral, intellectual, physical, aesthetic, and labor competencies.