Abstract: Physical chemistry is a compulsory foundational course for pharmacy majors.Characterized by strong theoretical content,abstract concepts,and limited instructional hours,it presents significant learning challenges.Traditional teaching models often overemphasize theoretical instruction while neglecting the cultivation of students' comprehensive competencies,and they tend to isolate the course from other pharmacy-related disciplines,thereby reducing student engagement.The implementation of a project-based flipped classroom approach can stimulate students' interest,enhance learning outcomes,and develop essential skills such as teamwork,communication,and higher-order thinking.