Abstract: With the advancement of the "New Medicine" and "Healthy China" strategies,the Traditional Chinese Medicine (TCM) industry has rapidly developed,and the demand for innovative and composite TCM professionals in society continues to increase.Capital Medical University has formulated an incentive policy for innovation and entrepreneurship,established a course on innovation and entrepreneurship,created a project library for innovation and entrepreneurship,organized a series of activities on innovation and entrepreneurship themes,integrated educational resources,and summarized a set of models for cultivating innovation and entrepreneurship capacity.The "Five Ones" initiative is implemented to promote the improvement of innovation and entrepreneurship capacity among Chinese Materia Medica undergraduates.