Abstract: Course construction is a core element in the cultivation of professional talent in higher education.In response to the Ministry of Education's launch of the "Double Ten Thousand Plan" for first-class undergraduate courses,Tianjin University of Traditional Chinese Medicine has actively pursued curriculum reform to create "golden courses",with Chemistry of Traditional Chinese Medicine selected as one of the first national-level offline first-class undergraduate courses.Using the construction and reform of this course as an example,this paper presents the course objectives,content,teaching design,and evaluation methods.The study provides a reference for the development of first-class undergraduate courses in Chinese medicine and opens new pathways for cultivating professionals with comprehensive practical skills and exceptional innovative capabilities.