Abstract: Taking the 2021 cohort of pharmacy students at the School of Pharmacy, Shanghai University of Medicine ＆ Health Sciences as the research sample, this study explores the integration of knowledge instruction and competency cultivation into the teaching of physical chemistry through a blended online-offline model.The teaching practice demonstrates that actively reforming and optimizing the introductory course can significantly enhance student engagement, reduce learning anxiety toward the subject, and lay a solid foundation for improving the overall effectiveness of physical chemistry education in pharmacy programs.