Abstract: By comparing the overall ideological and political performance, teaching effectiveness, and teaching satisfaction between an in-class and out-of-class integrated ideological and political curriculum and the traditional in-class ideological and political curriculum, this study analyzed the teaching outcomes of integrating ideological and political education into pathophysiology.Undergraduates from the 2021 cohort majoring in Clinical Medicine at Jiamusi University were randomly divided into two groups: the experimental group received in-class and out-of-class integrated ideological and political teaching, while the control group received only in-class ideological and political teaching.The two groups were compared in terms of overall performance, teaching effectiveness, and satisfaction.The results indicated that pathophysiology is well-suited for the implementation of an in-class and out-of-class integrated ideological and poli-tical approach, which effectively enhances academic achievement, problem-solving ability, and students’ overall competence.Therefore, this integrated curriculum design holds significant potential for broader application and promotion.